Oral minoxidil is becoming an increasingly popular treatment option for hair loss patients. This article will discuss a few background points regarding this phenomenon. LOW-DOSE ORAL MINOXIDIL FOR HAIR GROWTH Over the past 3-4 years, the prescription and use of oral minoxidil for hair loss has increased. This trend was likely driven by several peer-reviewed studies published around 2019/2020, including a study done at the Ramon y Cajal University Hospital in Spain, and a paper published in 2020 by Antonella Tosti and Michael Randolph, both appeared in the Journal of American Academy of Dermatology. Both studies presented an overall favorable opinion of the use of oral minoxidil for androgenic alopecia, and the latter concluded that it “was found to be an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations.” Dating back to over 50 years ago, oral minoxidil first showed signs of hypertrichosis in patients who were using the drug as a hypertensive agent, or a treatment to lower blood pressure. Several years later, a topical formulation of minoxidil was developed, and in 1988 the first version of 2% Regaine was launched in the UK as a treatment for pattern hair loss. Presumably, regulatory agencies and the pharmaceutical company who was developing minoxidil for hypertension had concerns about using it as a systemic treatment for hair loss. For over the past 30 years, topical minoxidil has been a staple hair loss treatment and a household name, as one of the only 2 FDA approved treatments for hair loss. Topical use of the product has come with mixed results among patients, mostly due to the varying amounts person-to-person of sulfotransferase, or SULT1A1, enzymes which are found in one’s hair follicles. The SULT1A1 enzyme is needed to convert minoxidil to its active form minoxidil sulfate within the hair follicle in order for the drug to promote a significant hair growth effect. It is a common theory that oral minoxidil outperforms topical minoxidil in hair growth efficacy due to facts that 1) the liver converts minoxidil into its sulfated form via phenol sulfotransferase and negates the need for hair follicle SULT1A1 levels and 2) the treatment naturally goes systemic and is more present in the bloodstream. Low-dose oral minoxidil is established to be at a dose of 5mg or lower. DISCUSSION Interest from multiple readers of this site prompted me to write about the use of low-dose oral minoxidil (OM) for hair growth, otherwise, I figured that most people were already aware of the possibility of getting this drug prescribed to them. Throughout various messaging channels on the internet, it is possible to find a multitude of testimonials from users of oral minoxidil, many positive, and some of them show very impressive results. Alternatively, you can also find remarks from users who experienced adverse effects from the drug and subsequently discontinued its use. A topic for which I have yet to find literature for, and one which I think deserves attention, is suggesting the lowest efficacious dose of OM for AGA, or “microdosing” OM. For a dermatologist’s perspective on the use of low-dose OM for AGA, see a review written for the JAAD which includes clinical trial data and mentions the warnings associated with the drug. Several years from now, it may be possible to evaluate longer term use of low-dose OM for AGA and compare its safety to the relatively short-term studies linked above, which were found to be generally favorable. Low-dose oral minoxidil should always be used under doctor’s supervision. from Follicle Thought
Holi 2023: Holi is one of the biggest Hindu festivals that celebrates the victory of good over evil. Is Holi on March 7 or 8? Find out the correct date, history, significance, shubh muhurat, celebrations, and all you need to know about the festival of colours inside. Holi - the festival of colours - is right around the corner. It is celebrated with much pomp by Hindus all across the globe and is one of the biggest festivals in India after Diwali. The celebrations last for two days - beginning with Choti Holi or Holika Dahan, followed by Dhulandi or Rangwali Holi. The occasion marks the victory of good over evil. It falls in the Hindu calendar month of Phalgun - falling between February and March. People celebrate the day with colours, water, balloons and flowers. Children and adults smear Gulal on each other and seek blessings from their elders. They also visit friends and relatives to commemorate the auspicious, grand celebration and relish Holi delicacies like gujiya, thandai and more. If you wish to know more about this festival, like the correct date, history, significance, celebrations, shubh muhurat, puja vidhi and more, check it out below. Holi 2023 Date: When is Holi and its shubh muhurat? This year, Holi falls on March 8, and Holika Dahan falls on March 7. According to Drik Panchang, Purnima tithi begins at 04:17 pm on March 6 and ends at 06:09 pm on March 7. The Holika Dahan tithi will last from 06:24 pm to 08:51 pm on March 7. Additionally, the Bhadra Punchha will be from 12:43 am to 02:01 am, and the Bhadra Mukha is from 02:01 am to 04:11 am. Holi 2023 History and Significance: Holi is a celebration of the divine love between Lord Krishna and Radha and the victory of good over evil. It is also marked as a harvest festival, commemorating spring's arrival and the end of winter. According to Hindu mythology, Lord Krishna was dark in complexion, and Radha was very fair. Krishna used to be anxious if Radha would accept him because of their opposite skin colour and complained to his mother, Yashoda. One day, Yashoda playfully suggested Krishna smear Radha's face with colour to remove any differences. Krishna followed his mother's advice and smeared Radha's face with Gulal. And that is how people began celebrating Holi. Another legend associated with Holi elaborates the story of king Hiranyakashipu, his son Prahalad - a devotee of Lord Vishnu, and his demoness aunt, Holika. Indian mythology says that Hiranyakashipu was blessed with a boon - he could not be killed by a man or animal. Therefore, he forced people to worship him. However, when his son became a devotee of Lord Vishnu and refused to worship him, Hiranyakashipu asked his sister Holika to kill him by sitting on a pyre while wearing a flame-shielding cloth. However, Prahlad prayed to Lord Vishnu to protect him - summoning a gust of wind that transferred the cloth from Holika to him. Thus, a day before Holi, Holika Dahan is celebrated to mark the victory of good over evil. Holi 2023 Celebrations: The auspicious festival of Holi is celebrated with pomp in places related to Lord Krishna, known as the Braj regions - Mathura, Vrindavan, Gowardhan, Gokul, Nandagaon and Barsana. The Lathmar Holi - the traditional Holi festivity in Barsana - and Phoolwali Holi in Vrindavan are world famous. Meanwhile, the festival is marked for two days - Chhoti Holi or Holika Dahan and Rangwali Holi or Dhulandi. During Holika Dahan, people light a bonfire to signify the victory of good over evil. On the next day, they wake up early in the morning to play with colours or Gulal. Children fill balloons and toy guns with water and play with their friends. People also relish sweet delicacies and thandai specially prepared for the festival. from Hindustan Times
Here’s how you can have a safe Holi This year, Holi falls on March 8, and Holika Dahan falls on March 7. Holi is all about fun, food, festivities and colour! But, it can land you in a soup with damaged hair, skin, rashes and breathing problems. Courtesy- toxic chemicals present in colours. Health 360 tells you how you can have a safe Holi. Easy Rosemary Hair Growth Spray * 10 drops rosemary essential oil * 1/2 teaspoon of a carrier oil (coconut oil, jojoba oil, or squalane oil) * 4 ounces distilled water * 4 ounces spray bottle (amber bottles like this will keep the essential oil potent longer) * mini funnel (optional but helpful) Instructions * Add 10 drops of rosemary essential oil to a 1/2 teaspoon and fill the rest of the teaspoon with a carrier oil. * Pour your oils into your bottle and fill the rest of the bottle to the top with water. Give your bottle a shake and spray directly into roots and then rub it in with your fingers a bit. * Spray into hair once a day. That's it. from A Beautiful Mess |
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